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Tumor Mutational Burden, Toxicity and Response of Immune Checkpoint Inhibitors Targeting PD(L)1, CTLA-4, and Combination: A Meta-Regression Analysis

PURPOSE: Tumor mutational burden (TMB) has emerged as a potential predictive biomarker for clinical response to ICI therapy, but whether TMB also predicts toxicity remains unknown. We investigated the relationship between TMB, objective response rate (ORR), overall survival (OS), and toxicity for IC...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Osipov, Arsen, Lim, Su Jin, Popovic, Aleksandra, Azad, Nilofer S, Laheru, Daniel A., Zheng, Lei, Jaffee, Elizabeth M., Wang, Hao, Yarchoan, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7501151/
https://ncbi.nlm.nih.gov/pubmed/32586938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-0458
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