Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer

The cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4)/B7 and programmed death 1 (PD-1)/ programmed cell death-ligand 1 (PD-L1) are two most representative immune checkpoint pathways, which negatively regulate T cell immune function during different phases of T-cell activation. Inhibitors targetin...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Zhang, Hao, Dai, Ziyu, Wu, Wantao, Wang, Zeyu, Zhang, Nan, Zhang, Liyang, Zeng, Wen-Jing, Liu, Zhixiong, Cheng, Quan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178863/
https://ncbi.nlm.nih.gov/pubmed/34088360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-021-01987-7
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