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Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells

A genome-wide small-interfering RNA-based screen identified the transcription factor Specificity Protein 3 (SP3) as a critical factor for Second mitochondrial-derived activator of caspase (Smac) mimetic-mediated killing of cancer cells. In concert with Nuclear Factor kappa B (NF-κB,) SP3 is required...

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Publicado en:Mol Cell Oncol
Main Authors: Beug, Shawn T., Korneluk, Robert G., LaCasse, Eric C.
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548490/
https://ncbi.nlm.nih.gov/pubmed/31211235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2019.1607456
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