Cytoplasmic TDP-43 de-mixing independent of stress granules drives inhibition of nuclear import, loss of nuclear TDP-43, and cell death

While cytoplasmic aggregation of TDP-43 is a pathological hallmark of amyotrophic lateral sclerosis and frontotemporal dementia, how aggregates form and what drives its nuclear clearance have not been determined. Here we show that TDP-43 at its endogenous level undergoes liquid-liquid phase separati...

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Veröffentlicht in:Neuron
Hauptverfasser: Gasset-Rosa, Fatima, Lu, Shan, Yu, Haiyang, Chen, Cong, Melamed, Zevik, Guo, Lin, Shorter, James, Da Cruz, Sandrine, Cleveland, Don W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548321/
https://ncbi.nlm.nih.gov/pubmed/30853299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.02.038
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