Construction and benchmarking of a multi-ethnic reference panel for the imputation of HLA class I and II alleles

Genotype imputation of the human leukocyte antigen (HLA) region is a cost-effective means to infer classical HLA alleles from inexpensive and dense SNP array data. In the research setting, imputation helps avoid costs for wet lab-based HLA typing and thus renders association analyses of the HLA in l...

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Publié dans:Hum Mol Genet
Auteurs principaux: Degenhardt, Frauke, Wendorff, Mareike, Wittig, Michael, Ellinghaus, Eva, Datta, Lisa W, Schembri, John, Ng, Siew C, Rosati, Elisa, Hübenthal, Matthias, Ellinghaus, David, Jung, Eun Suk, Lieb, Wolfgang, Abedian, Shifteh, Malekzadeh, Reza, Cheon, Jae Hee, Ellul, Pierre, Sood, Ajit, Midha, Vandana, Thelma, B K, Wong, Sunny H, Schreiber, Stefan, Yamazaki, Keiko, Kubo, Michiaki, Boucher, Gabrielle, Rioux, John D, Lenz, Tobias L, Brant, Steven R, Franke, Andre
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Bioinformatics Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548229/
https://ncbi.nlm.nih.gov/pubmed/30590525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy443
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