Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem

Rap1 GTPases bind effectors, such as RIAM, to enable talin1 to induce integrin activation. In addition, Rap1 binds directly to the talin1 F0 domain (F0); however, this interaction makes a limited contribution to integrin activation in CHO cells or platelets. Here, we show that talin1 F1 domain (F1)...

Full description

Saved in:
Bibliographic Details
Published in:J Cell Biol
Main Authors: Gingras, Alexandre R., Lagarrigue, Frederic, Cuevas, Monica N., Valadez, Andrew J., Zorovich, Marcus, McLaughlin, Wilma, Lopez-Ramirez, Miguel Alejandro, Seban, Nicolas, Ley, Klaus, Kiosses, William B., Ginsberg, Mark H.
Format: Artigo
Language:Inglês
Published: Rockefeller University Press 2019
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548133/
https://ncbi.nlm.nih.gov/pubmed/30988001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201810061
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items