The PHLPP2 phosphatase is a druggable driver of prostate cancer progression

Metastatic prostate cancer commonly presents with targeted, bi-allelic mutations of the PTEN and TP53 tumor suppressor genes. In contrast, however, most candidate tumor suppressors are part of large recurrent hemizygous deletions, such as the common chromosome 16q deletion, which involves the AKT-su...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Nowak, Dawid G., Katsenelson, Ksenya Cohen, Watrud, Kaitlin E., Chen, Muhan, Mathew, Grinu, D’Andrea, Vincent D., Lee, Matthew F., Swamynathan, Manojit Mosur, Casanova-Salas, Irene, Jibilian, Megan C., Buckholtz, Caroline L., Ambrico, Alexandra J., Pan, Chun-Hao, Wilkinson, John E., Newton, Alexandra C., Trotman, Lloyd C.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548123/
https://ncbi.nlm.nih.gov/pubmed/31092557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201902048
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