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Nickel-Catalyzed Asymmetric C-Alkylation of Nitroalkanes: Synthesis of Enantioenriched β-Nitroamides

A general catalytic method for asymmetric C-alkylation of nitroalkanes using nickel catalysis is described. This method enables the formation of highly enantioenriched β-nitroamides from readily available α-bromoamides using mild reaction conditions that are compatible with a wide range of functiona...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Devannah, Vijayarajan, Sharma, Rajgopal, Watson, Donald A.
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547819/
https://ncbi.nlm.nih.gov/pubmed/31082224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b04175
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