The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing

DNA replication initiation is a two-step process. During the G1-phase of the cell cycle, the ORC complex, CDC6, CDT1, and MCM2–7 assemble at replication origins, forming pre-replicative complexes (pre-RCs). In S-phase, kinase activities allow fork establishment through (CDC45/MCM2–7/GINS) CMG-comple...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Coulombe, Philippe, Nassar, Joelle, Peiffer, Isabelle, Stanojcic, Slavica, Sterkers, Yvon, Delamarre, Axel, Bocquet, Stéphane, Méchali, Marcel
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547688/
https://ncbi.nlm.nih.gov/pubmed/31160578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10321-x
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