Genome-scale analysis of metazoan replication origins reveals their organization in specific but flexible sites defined by conserved features

In metazoans, thousands of DNA replication origins (Oris) are activated at each cell cycle. Their genomic organization and their genetic nature remain elusive. Here, we characterized Oris by nascent strand (NS) purification and a genome-wide analysis in Drosophila and mouse cells. We show that in bo...

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Bibliografiske detaljer
Main Authors: Cayrou, Christelle, Coulombe, Philippe, Vigneron, Alice, Stanojcic, Slavica, Ganier, Olivier, Peiffer, Isabelle, Rivals, Eric, Puy, Aurore, Laurent-Chabalier, Sabine, Desprat, Romain, Méchali, Marcel
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2011
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166829/
https://ncbi.nlm.nih.gov/pubmed/21750104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.121830.111
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