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Activated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial dome

The germinal center (GC) reaction in Peyer′s patches (PP) requires continuous access to antigens, but how this is achieved is not known. Here we show that activated antigen-specific CCR6(+)CCR1(+)GL7(−) B cells make close contact with M cells in the subepithelial dome (SED). Using in situ photoactiv...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Komban, Rathan Joy, Strömberg, Anneli, Biram, Adi, Cervin, Jakob, Lebrero-Fernández, Cristina, Mabbott, Neil, Yrlid, Ulf, Shulman, Ziv, Bemark, Mats, Lycke, Nils
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547658/
https://ncbi.nlm.nih.gov/pubmed/31160559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10144-w
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