Activated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial dome

The germinal center (GC) reaction in Peyer′s patches (PP) requires continuous access to antigens, but how this is achieved is not known. Here we show that activated antigen-specific CCR6(+)CCR1(+)GL7(−) B cells make close contact with M cells in the subepithelial dome (SED). Using in situ photoactiv...

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Publicado en:Nat Commun
Autores principales: Komban, Rathan Joy, Strömberg, Anneli, Biram, Adi, Cervin, Jakob, Lebrero-Fernández, Cristina, Mabbott, Neil, Yrlid, Ulf, Shulman, Ziv, Bemark, Mats, Lycke, Nils
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547658/
https://ncbi.nlm.nih.gov/pubmed/31160559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10144-w
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