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N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradation

The telomerase holoenzyme responsible for maintaining telomeres in vertebrates requires many components in vivo, including dyskerin. Dyskerin binds and regulates the accumulation of the human telomerase RNA, hTR, as well as other non-coding RNAs that share the conserved H/ACA box motif. The precise...

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Publicat a:Nucleic Acids Res
Autors principals: MacNeil, Deanna E, Lambert-Lanteigne, Patrick, Autexier, Chantal
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547437/
https://ncbi.nlm.nih.gov/pubmed/30931479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz233
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