Charting DENR-dependent translation reinitiation uncovers predictive uORF features and links to circadian timekeeping via Clock

The non-canonical initiation factor DENR promotes translation reinitiation on mRNAs harbouring upstream open reading frames (uORFs). Moreover, DENR depletion shortens circadian period in mouse fibroblasts, suggesting involvement of uORF usage and reinitiation in clock regulation. To identify DENR-re...

Full description

Saved in:
Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Castelo-Szekely, Violeta, De Matos, Mara, Tusup, Marina, Pascolo, Steve, Ule, Jernej, Gatfield, David
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Genomics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547434/
https://ncbi.nlm.nih.gov/pubmed/30982898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz261
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items