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Location dependence of the transcriptional response of a potential G-quadruplex in gene promoters under oxidative stress
Oxidation of the guanine (G) heterocycle to 8-oxo-7,8-dihydroguanine (OG) in mammalian gene promoters was demonstrated to induce transcription. Potential G-quadruplex forming sequences (PQSs) in promoters have a high density of G nucleotides rendering them highly susceptible to oxidation and possibl...
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| Publicado no: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6547423/ https://ncbi.nlm.nih.gov/pubmed/30916339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz207 |
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