Carbonyl Reduction of Flubendazole in the Human Liver: Strict Stereospecificity, Sex Difference, Low Risk of Drug Interactions

Flubendazole (FLU), an anthelmintic drug of benzimidazole type, is now considered a promising anti-cancer agent due to its tubulin binding ability and low system toxicity. The present study was aimed at determining more information about FLU reduction in human liver, because this information has bee...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Kubíček, Vladimír, Skálová, Lenka, Skarka, Adam, Králová, Věra, Holubová, Jana, Štěpánková, Jana, Šubrt, Zdeněk, Szotáková, Barbora
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546852/
https://ncbi.nlm.nih.gov/pubmed/31191322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00600
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