Carbonyl Reduction of Flubendazole in the Human Liver: Strict Stereospecificity, Sex Difference, Low Risk of Drug Interactions

Flubendazole (FLU), an anthelmintic drug of benzimidazole type, is now considered a promising anti-cancer agent due to its tubulin binding ability and low system toxicity. The present study was aimed at determining more information about FLU reduction in human liver, because this information has bee...

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Bibliografiske detaljer
Udgivet i:Front Pharmacol
Main Authors: Kubíček, Vladimír, Skálová, Lenka, Skarka, Adam, Králová, Věra, Holubová, Jana, Štěpánková, Jana, Šubrt, Zdeněk, Szotáková, Barbora
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546852/
https://ncbi.nlm.nih.gov/pubmed/31191322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00600
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