Hemoglobin β93 cysteine is not required for export of nitric oxide bioactivity from the red blood cell.

BACKGROUND: Nitrosation of a conserved cysteine residue at position 93 in the hemoglobin β-chain (β93C) to form S-nitroso hemoglobin (SNO-Hb) is claimed to be essential for export of NO bioactivity by the red blood cell (RBC) to mediate hypoxic vasodilation and cardioprotection. METHODS: To test thi...

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Udgivet i:Circulation
Main Authors: Sun, Chiao-Wang, Yang, Jiangning, Kleschyov, Andrei, Zhuge, Zhengbing, Carlström, Mattias, Pernow, John, Wajih, Nadeem, Isbell, T. Scott, Oh, Joo-Yeun, Cabrales, Pedro, Tsai, Amy, Townes, Tim, Kim-Shapiro, Daniel B., Patel, Rakesh P., Lundberg, Jon O.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546526/
https://ncbi.nlm.nih.gov/pubmed/30905171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.118.039284
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