Essential role of hemoglobin beta-93-cysteine in posthypoxia facilitation of breathing in conscious mice

When erythrocyte hemoglobin (Hb) is fully saturated with O(2), nitric oxide (NO) covalently binds to the cysteine 93 residue of the Hb β-chain (B93-CYS), forming S-nitrosohemoglobin. Binding of NO is allosterically coupled to the O(2) saturation of Hb. As saturation falls, the NO group on B93-CYS is...

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Bibliographic Details
Main Authors: Gaston, Benjamin, May, Walter J., Sullivan, Spencer, Yemen, Sean, Marozkina, Nadzeya V., Palmer, Lisa A., Bates, James N., Lewis, Stephen J.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2014
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4044395/
https://ncbi.nlm.nih.gov/pubmed/24610531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.01050.2013
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