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Essential role of hemoglobin beta-93-cysteine in posthypoxia facilitation of breathing in conscious mice

When erythrocyte hemoglobin (Hb) is fully saturated with O(2), nitric oxide (NO) covalently binds to the cysteine 93 residue of the Hb β-chain (B93-CYS), forming S-nitrosohemoglobin. Binding of NO is allosterically coupled to the O(2) saturation of Hb. As saturation falls, the NO group on B93-CYS is...

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Detalhes bibliográficos
Main Authors: Gaston, Benjamin, May, Walter J., Sullivan, Spencer, Yemen, Sean, Marozkina, Nadzeya V., Palmer, Lisa A., Bates, James N., Lewis, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4044395/
https://ncbi.nlm.nih.gov/pubmed/24610531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.01050.2013
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