Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling

The nuclear protein DEK is an endogenous DNA-binding chromatin factor regulating hematopoiesis. DEK is one of only 2 known secreted nuclear chromatin factors, but whether and how extracellular DEK regulates hematopoiesis is not known. We demonstrated that extracellular DEK greatly enhanced ex vivo e...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Capitano, Maegan L., Mor-Vaknin, Nirit, Saha, Anjan K., Cooper, Scott, Legendre, Maureen, Guo, Haihong, Contreras-Galindo, Rafael, Kappes, Ferdinand, Sartor, Maureen A., Lee, Christopher T., Huang, Xinxin, Markovitz, David M., Broxmeyer, Hal E.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546479/
https://ncbi.nlm.nih.gov/pubmed/31107242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127460
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