Identifying cis elements for spatio-temporal control of mammalian DNA replication

The temporal order of DNA replication (replication timing, RT) is highly coupled with genome architecture, but cis-elements regulating either remain elusive. We created a series of CRISPR-mediated deletions and inversions of a pluripotency-associated topologically associating domain (TAD) in mouse e...

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Xehetasun bibliografikoak
Argitaratua izan da:Cell
Egile Nagusiak: Sima, Jiao, Chakraborty, Abhijit, Dileep, Vishnu, Michalski, Marco, Klein, Kyle N., Holcomb, Nicolas P., Turner, Jesse L., Paulsen, Michelle T., Rivera-Mulia, Juan Carlos, Trevilla-Garcia, Claudia, Bartlett, Daniel A., Zhao, Peiyao A., Washburn, Brian K., Nora, Elphège P., Kraft, Katerina, Mundlos, Stefan, Bruneau, Benoit G., Ljungman, Mats, Fraser, Peter, Ay, Ferhat, Gilbert, David M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546437/
https://ncbi.nlm.nih.gov/pubmed/30595451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.11.036
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