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Inhibition of protein nitration prevents cisplatin-induced inactivation of STAT3 and promotes anti-apoptotic signaling in organ of Corti cells

JAK/STAT pathway is one among the several oxidative stress-responsive signaling pathways that play a critical role in facilitating cisplatin-induced ototoxicity. Cisplatin treatment decreases the levels of cochlear LMO4, which acts as a scaffold for IL6-GP130 protein complex. Cisplatin-induced nitra...

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Vydáno v:Exp Cell Res
Hlavní autoři: Rosati, Rita, Shahab, Monazza, Neumann, William L., Jamesdaniel, Samson
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546436/
https://ncbi.nlm.nih.gov/pubmed/31078568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2019.05.008
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