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Lmo4 Deficiency Enhances Susceptibility to Cisplatin-Induced Cochlear Apoptosis and Hearing Loss
Cisplatin, a potent chemotherapeutic drug, induces ototoxicity, which limits its clinical utility. Cisplatin-induced oxidative stress plays a causal role in cochlear apoptosis while the consequent nitrative stress leads to the nitration of LIM domain only-4 (LMO4), a transcriptional regulator, and d...
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| Publicado no: | Mol Neurobiol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8026651/ https://ncbi.nlm.nih.gov/pubmed/33411315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-020-02226-4 |
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