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CRISPR/Cas9-mediated knockout of Lim-domain only four retards organ of Corti cell growth
Lim-domain only 4 (LMO4) plays a critical role in mediating the ototoxic side-effects of cisplatin, a highly effective anti-cancer drug. However, the signaling mechanism by which cochlear LMO4 mediates otopathology is yet to be fully understood. Knockout cell culture models are useful tools for inve...
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| Veröffentlicht in: | J Cell Biochem |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6366322/ https://ncbi.nlm.nih.gov/pubmed/29143984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.26529 |
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