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Determinants of dopaminergic neuron loss in Parkinson’s disease

The cardinal motor symptoms of Parkinson’s disease (PD) are caused by the death of dopaminergic neurons in the substantia nigra pars compacta (SNc). Alpha-synuclein (aSYN) pathology and mitochondrial dysfunction have been implicated in PD pathogenesis, but until recently it was unclear why SNc dopam...

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Bibliografiska uppgifter
I publikationen:FEBS J
Huvudupphovsman: Surmeier, D. James
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546423/
https://ncbi.nlm.nih.gov/pubmed/30028088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.14607
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