Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase

DOT1L is a histone H3 Lys79 methyltransferase whose activity is stimulated by histone H2B Lys120 ubiquitination, suggesting cross-talk between histone H3 methylation and H2B ubiquitination. Here, we present cryo-EM structures of DOT1L complexes with unmodified or H2B ubiquitinated nucleosomes, showi...

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Библиографические подробности
Опубликовано в: :Genes Dev
Главные авторы: Jang, Seongmin, Kang, Chanshin, Yang, Han-Sol, Jung, Taeyang, Hebert, Hans, Chung, Ka Young, Kim, Seung Joong, Hohng, Sungchul, Song, Ji-Joon
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory Press 2019
Предметы:
Research Communication
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546062/
https://ncbi.nlm.nih.gov/pubmed/30923167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.323790.118
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