Hippocampal Genetic Knockdown of PPARδ Causes Depression-Like Behaviors and Neurogenesis Suppression

BACKGROUND: Although depression is the leading cause of disability worldwide, its pathophysiology is poorly understood. Our previous study showed that hippocampal peroxisome proliferator-activated receptor δ (PPARδ) overexpression displays antidepressive effect and enhances hippocampal neurogenesis...

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Bibliografiske detaljer
Udgivet i:Int J Neuropsychopharmacol
Main Authors: Chen, Fang, Yu, Xuben, Meng, Guoliang, Mei, Zhenlin, Du, Yifeng, Sun, Hongbin, Reed, Miranda N, Kong, Lingyi, Suppiramaniam, Vishnu, Hong, Hao, Tang, Susu
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Regular Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6545535/
https://ncbi.nlm.nih.gov/pubmed/31038173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyz008
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