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Hematopoietic knockdown of PPARδ reduces atherosclerosis in LDLR −/− mice
PPAR(δ) (peroxisome proliferator-activated receptor δ) mediates inflammation in response to lipid accumulation. Systemic administration of a PPAR(δ) agonist can ameliorate atherosclerosis. Paradoxically, genetic deletion of PPAR(δ) in hematopoietic cells led to a reduction of atherosclerosis in muri...
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| Publicado no: | Gene Ther |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4939901/ https://ncbi.nlm.nih.gov/pubmed/26204499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2015.78 |
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