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Hematopoietic knockdown of PPARδ reduces atherosclerosis in LDLR −/− mice
PPAR(δ) (peroxisome proliferator-activated receptor δ) mediates inflammation in response to lipid accumulation. Systemic administration of a PPAR(δ) agonist can ameliorate atherosclerosis. Paradoxically, genetic deletion of PPAR(δ) in hematopoietic cells led to a reduction of atherosclerosis in muri...
Tallennettuna:
| Julkaisussa: | Gene Ther |
|---|---|
| Päätekijät: | , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2015
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4939901/ https://ncbi.nlm.nih.gov/pubmed/26204499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2015.78 |
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