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H(2)O(2) induces nuclear transport of the receptor tyrosine kinase c-MET in breast cancer cells via a membrane-bound retrograde trafficking mechanism
Reactive oxygen species (ROS) are cellular by-products produced from metabolism and also anticancer agents, such as ionizing irradiation and chemotherapy drugs. The ROS H(2)O(2) has high rates of production in cancer cells because of their rapid proliferation. ROS oxidize DNA, protein, and lipids, c...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6544865/ https://ncbi.nlm.nih.gov/pubmed/30962283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005953 |
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