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Identification of a hinge residue controlling islet amyloid polypeptide self-assembly and cytotoxicity

The islet amyloid polypeptide (IAPP) is a 37-residue peptide hormone whose deposition as amyloid fibrils in the pancreatic islets is associated with type 2 diabetes. Previous studies have suggested that residue Asn-21 plays a critical role in the in vitro self-assembly of IAPP. Herein, we studied st...

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Publicat a:J Biol Chem
Autors principals: Godin, Elizabeth, Nguyen, Phuong Trang, Zottig, Ximena, Bourgault, Steve
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544841/
https://ncbi.nlm.nih.gov/pubmed/30975901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006454
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