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Identification of a hinge residue controlling islet amyloid polypeptide self-assembly and cytotoxicity
The islet amyloid polypeptide (IAPP) is a 37-residue peptide hormone whose deposition as amyloid fibrils in the pancreatic islets is associated with type 2 diabetes. Previous studies have suggested that residue Asn-21 plays a critical role in the in vitro self-assembly of IAPP. Herein, we studied st...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6544841/ https://ncbi.nlm.nih.gov/pubmed/30975901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006454 |
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