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Farnesoid X receptor represses matrix metalloproteinase 7 expression, revealing this regulatory axis as a promising therapeutic target in colon cancer

The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily of bile acid–activated transcription factors and an important regulator of cell proliferation, apoptosis, and Wnt signaling. Down-regulated expression of FXR plays an important role in some malignancies such as colon canc...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Peng, Zhongsheng, Chen, Jiayan, Drachenberg, Cinthia B., Raufman, Jean-Pierre, Xie, Guofeng
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544837/
https://ncbi.nlm.nih.gov/pubmed/30967475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004361
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