The histone deacetylase inhibitor Romidepsin induces as a cascade of differential gene expression and altered histone H3K9 marks in myeloid leukaemia cells

Myelodysplastic syndromes (MDS) are a heterogeneous, clonal haematopoietic disorder, with ~1/3 of patients progressing to acute myeloid leukaemia (AML). Many elderly MDS patients do not tolerate intensive therapeutic regimens, and therefore have an unmet need for better tolerated therapies. Epigenet...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncotarget
Prif Awduron: Clarke, Kathryn, Young, Christine, Liberante, Fabio, McMullin, Mary-Frances, Thompson, Alexander, Mills, Ken
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2019
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544403/
https://ncbi.nlm.nih.gov/pubmed/31191819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26877
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