The histone deacetylase inhibitor Romidepsin induces as a cascade of differential gene expression and altered histone H3K9 marks in myeloid leukaemia cells

Myelodysplastic syndromes (MDS) are a heterogeneous, clonal haematopoietic disorder, with ~1/3 of patients progressing to acute myeloid leukaemia (AML). Many elderly MDS patients do not tolerate intensive therapeutic regimens, and therefore have an unmet need for better tolerated therapies. Epigenet...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Clarke, Kathryn, Young, Christine, Liberante, Fabio, McMullin, Mary-Frances, Thompson, Alexander, Mills, Ken
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2019
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544403/
https://ncbi.nlm.nih.gov/pubmed/31191819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26877
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