Intradermal DNA vaccination combined with dual CTLA-4 and PD-1 blockade provides robust tumor immunity in murine melanoma

We aimed to explore whether the combination of intradermal DNA vaccination, to boost immune response against melanoma antigens, and immune checkpoint blockade, to alleviate immunosuppression, improves antitumor effectiveness in a murine B16F10 melanoma tumor model. Compared to single treatments, a c...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Kos, Spela, Lopes, Alessandra, Preat, Veronique, Cemazar, Maja, Lampreht Tratar, Ursa, Ucakar, Bernard, Vanvarenberg, Kevin, Sersa, Gregor, Vandermeulen, Gaelle
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544376/
https://ncbi.nlm.nih.gov/pubmed/31150505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217762
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