Intradermal DNA vaccination combined with dual CTLA-4 and PD-1 blockade provides robust tumor immunity in murine melanoma

We aimed to explore whether the combination of intradermal DNA vaccination, to boost immune response against melanoma antigens, and immune checkpoint blockade, to alleviate immunosuppression, improves antitumor effectiveness in a murine B16F10 melanoma tumor model. Compared to single treatments, a c...

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Vydáno v:PLoS One
Hlavní autoři: Kos, Spela, Lopes, Alessandra, Preat, Veronique, Cemazar, Maja, Lampreht Tratar, Ursa, Ucakar, Bernard, Vanvarenberg, Kevin, Sersa, Gregor, Vandermeulen, Gaelle
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544376/
https://ncbi.nlm.nih.gov/pubmed/31150505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217762
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