Intradermal DNA vaccination combined with dual CTLA-4 and PD-1 blockade provides robust tumor immunity in murine melanoma

We aimed to explore whether the combination of intradermal DNA vaccination, to boost immune response against melanoma antigens, and immune checkpoint blockade, to alleviate immunosuppression, improves antitumor effectiveness in a murine B16F10 melanoma tumor model. Compared to single treatments, a c...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kos, Spela, Lopes, Alessandra, Preat, Veronique, Cemazar, Maja, Lampreht Tratar, Ursa, Ucakar, Bernard, Vanvarenberg, Kevin, Sersa, Gregor, Vandermeulen, Gaelle
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544376/
https://ncbi.nlm.nih.gov/pubmed/31150505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217762
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