Bacterial cGAS-like enzymes synthesize diverse nucleotide signals

Cyclic dinucleotides (CDNs) play central roles in bacterial homeostasis and virulence as nucleotide second messengers. Bacterial CDNs also elicit immune responses during infection when they are detected by pattern recognition receptors in animal cells. Here, we performed a systematic biochemical scr...

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Udgivet i:Nature
Main Authors: Whiteley, Aaron T., Eaglesham, James B., de Oliveira Mann, Carina C., Morehouse, Benjamin R., Lowey, Brianna, Nieminen, Eric A., Danilchanka, Olga, King, David S., Lee, Amy S.Y., Mekalanos, John J., Kranzusch, Philip J.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544370/
https://ncbi.nlm.nih.gov/pubmed/30787435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-0953-5
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