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Reduced level of docosahexaenoic acid shifts GPCR neuroreceptors to less ordered membrane regions

G protein-coupled receptors (GPCRs) control cellular signaling and responses. Many of these GPCRs are modulated by cholesterol and polyunsaturated fatty acids (PUFAs) which have been shown to co-exist with saturated lipids in ordered membrane domains. However, the lipid compositions of such domains...

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Vydáno v:PLoS Comput Biol
Hlavní autoři: Javanainen, Matti, Enkavi, Giray, Guixà-Gonzaléz, Ramon, Kulig, Waldemar, Martinez-Seara, Hector, Levental, Ilya, Vattulainen, Ilpo
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544328/
https://ncbi.nlm.nih.gov/pubmed/31107861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007033
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