Drug combination sensitivity scoring facilitates the discovery of synergistic and efficacious drug combinations in cancer

High-throughput drug screening has facilitated the discovery of drug combinations in cancer. Many existing studies adopted a full matrix design, aiming for the characterization of drug pair effects for cancer cells. However, the full matrix design may be suboptimal as it requires a drug pair to be c...

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Bibliographic Details
Published in:PLoS Comput Biol
Main Authors: Malyutina, Alina, Majumder, Muntasir Mamun, Wang, Wenyu, Pessia, Alberto, Heckman, Caroline A., Tang, Jing
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544320/
https://ncbi.nlm.nih.gov/pubmed/31107860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006752
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