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Combined gene essentiality scoring improves the prediction of cancer dependency maps
BACKGROUND: Probing genetic dependencies of cancer cells can improve our understanding of tumour development and progression, as well as identify potential drug targets. CRISPR-Cas9-based and shRNA-based genetic screening are commonly utilized to identify essential genes that affect cancer growth. H...
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| Publié dans: | EBioMedicine |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Elsevier
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6923492/ https://ncbi.nlm.nih.gov/pubmed/31732481 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.10.051 |
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