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Pharmacokinetic parameters and mechanism of action of an efficient anti-Aβ single chain antibody fragment
The success of the targeting of amyloid-β (Aβ) oligomers through immunotherapy in Alzheimer’s disease (AD) mouse models has not been translated into the clinics. The use of single-chain variable fragments (scFvs) has been proposed to prevent the potential severe effects of full-length mAbs by preclu...
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| Опубликовано в: : | PLoS One |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6544282/ https://ncbi.nlm.nih.gov/pubmed/31150495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217793 |
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