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Epistasis detectably alters correlations between genomic sites in a narrow parameter window

Different genomic sites evolve inter-dependently due to the combined action of epistasis, defined as a non-multiplicative contribution of alleles at different loci to genome fitness, and the physical linkage of different loci in genome. Both epistasis and linkage, partially compensated by recombinat...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Pedruzzi, Gabriele, Rouzine, Igor M.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544209/
https://ncbi.nlm.nih.gov/pubmed/31150393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0214036
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