Probing Transient Non-Native States in Amyloid Beta Fiber Elongation by NMR

Using NMR to probe transient binding of Aβ(1–40) monomers to fibers, we find partially bound conformations with the highest degree of interaction near F19-K28 and a lesser degree of interaction near the C-terminus (L34-G37). This represents a shift away from the KLVFFA recognition sequence (residues...

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Detalhes bibliográficos
Publicado no:Chem Commun (Camb)
Main Authors: Brender, Jeffrey R., Ghosh, Anirban, Kotler, Samuel A., Krishnamoorthy, Janarthanan, Bera, Swapna, Morris, Vanessa, Sil, Timir Baran, Garai, Kanchan, Reif, Bernd, Bhunia, Anirban, Ramamoorthy, Ayyalusamy
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544147/
https://ncbi.nlm.nih.gov/pubmed/30917192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9cc01067j
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