Probing Transient Non-Native States in Amyloid Beta Fiber Elongation by NMR

Using NMR to probe transient binding of Aβ(1–40) monomers to fibers, we find partially bound conformations with the highest degree of interaction near F19-K28 and a lesser degree of interaction near the C-terminus (L34-G37). This represents a shift away from the KLVFFA recognition sequence (residues...

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Bibliografski detalji
Izdano u:Chem Commun (Camb)
Glavni autori: Brender, Jeffrey R., Ghosh, Anirban, Kotler, Samuel A., Krishnamoorthy, Janarthanan, Bera, Swapna, Morris, Vanessa, Sil, Timir Baran, Garai, Kanchan, Reif, Bernd, Bhunia, Anirban, Ramamoorthy, Ayyalusamy
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544147/
https://ncbi.nlm.nih.gov/pubmed/30917192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9cc01067j
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