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Identification and quantification of sites of nitration and oxidation in the key matrix protein laminin and the structural consequences of these modifications

Laminin is a major protein of the basement membrane (BM), a specialized extracellular matrix (ECM) of the artery wall. The potent oxidizing and nitrating agent peroxynitrous acid (ONOOH) is formed at sites of inflammation, and data implicate ONOOH in ECM damage and cardiovascular disease. Co-localiz...

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Publicat a:Redox Biol
Autors principals: Lorentzen, Lasse G., Chuang, Christine Y., Rogowska-Wrzesinska, Adelina, Davies, Michael J.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6543125/
https://ncbi.nlm.nih.gov/pubmed/31154162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101226
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