Systems biology identifies cytosolic PLA2 as a target in vascular calcification treatment

Although cardiovascular disease (CVD) is the leading cause of morbimortality worldwide, promising new drug candidates are lacking. We compared the arterial high-resolution proteome of patients with advanced versus early-stage CVD to predict, from a library of small bioactive molecules, drug candidat...

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Bibliografische gegevens
Gepubliceerd in:JCI Insight
Hoofdauteurs: Schanstra, Joost P., Luong, Trang T.D., Makridakis, Manousos, Van Linthout, Sophie, Lygirou, Vasiliki, Latosisnska, Agnieszka, Alesutan, Ioana, Boehme, Beate, Schelski, Nadeshda, Von Lewinski, Dirk, Mullen, William, Nicklin, Stuart, Delles, Christian, Feuillet, Guylène, Denis, Colette, Lang, Florian, Pieske, Burkert, Bascands, Jean-Loup, Mischak, Harald, Saulnier-Blache, Jean-Sebastien, Voelkl, Jakob, Vlahou, Antonia, Klein, Julie
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2019
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542631/
https://ncbi.nlm.nih.gov/pubmed/31092728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.125638
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