Systems biology identifies cytosolic PLA2 as a target in vascular calcification treatment

Although cardiovascular disease (CVD) is the leading cause of morbimortality worldwide, promising new drug candidates are lacking. We compared the arterial high-resolution proteome of patients with advanced versus early-stage CVD to predict, from a library of small bioactive molecules, drug candidat...

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Detalhes bibliográficos
Publicado no:JCI Insight
Principais autores: Schanstra, Joost P., Luong, Trang T.D., Makridakis, Manousos, Van Linthout, Sophie, Lygirou, Vasiliki, Latosisnska, Agnieszka, Alesutan, Ioana, Boehme, Beate, Schelski, Nadeshda, Von Lewinski, Dirk, Mullen, William, Nicklin, Stuart, Delles, Christian, Feuillet, Guylène, Denis, Colette, Lang, Florian, Pieske, Burkert, Bascands, Jean-Loup, Mischak, Harald, Saulnier-Blache, Jean-Sebastien, Voelkl, Jakob, Vlahou, Antonia, Klein, Julie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542631/
https://ncbi.nlm.nih.gov/pubmed/31092728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.125638
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