Phase I trial of the single-chain urokinase intrapleural LTI-01 in complicated parapneumonic effusions or empyema

BACKGROUND. Current dosing of intrapleural fibrinolytic therapy (IPFT) in adults with complicated parapneumonic effusion (CPE)/empyema is empiric, as dose-escalation trials have not previously been conducted. We hypothesized that LTI-01 (a single-chain urokinase [scuPA]), which is relatively resista...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Beckert, Lutz, Brockway, Ben, Simpson, Graham, Southcott, Anne Marie, Lee, Y.C. Gary, Rahman, Najib, Light, Richard W., Shoemaker, Steven, Gillies, John, Komissarov, Andrey A., Florova, Galina, Ochran, Timothy, Bradley, William, Ndetan, Harrison, Singh, Karan P., Sarva, Krishna, Idell, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Clinical Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542611/
https://ncbi.nlm.nih.gov/pubmed/30998508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127470
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