Phase I trial of the single-chain urokinase intrapleural LTI-01 in complicated parapneumonic effusions or empyema

BACKGROUND. Current dosing of intrapleural fibrinolytic therapy (IPFT) in adults with complicated parapneumonic effusion (CPE)/empyema is empiric, as dose-escalation trials have not previously been conducted. We hypothesized that LTI-01 (a single-chain urokinase [scuPA]), which is relatively resista...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:JCI Insight
Main Authors: Beckert, Lutz, Brockway, Ben, Simpson, Graham, Southcott, Anne Marie, Lee, Y.C. Gary, Rahman, Najib, Light, Richard W., Shoemaker, Steven, Gillies, John, Komissarov, Andrey A., Florova, Galina, Ochran, Timothy, Bradley, William, Ndetan, Harrison, Singh, Karan P., Sarva, Krishna, Idell, Steven
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Clinical Investigation 2019
נושאים:
Clinical Medicine
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542611/
https://ncbi.nlm.nih.gov/pubmed/30998508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127470
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