Phase I trial of the single-chain urokinase intrapleural LTI-01 in complicated parapneumonic effusions or empyema

BACKGROUND. Current dosing of intrapleural fibrinolytic therapy (IPFT) in adults with complicated parapneumonic effusion (CPE)/empyema is empiric, as dose-escalation trials have not previously been conducted. We hypothesized that LTI-01 (a single-chain urokinase [scuPA]), which is relatively resista...

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Bibliografske podrobnosti
izdano v:JCI Insight
Main Authors: Beckert, Lutz, Brockway, Ben, Simpson, Graham, Southcott, Anne Marie, Lee, Y.C. Gary, Rahman, Najib, Light, Richard W., Shoemaker, Steven, Gillies, John, Komissarov, Andrey A., Florova, Galina, Ochran, Timothy, Bradley, William, Ndetan, Harrison, Singh, Karan P., Sarva, Krishna, Idell, Steven
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2019
Teme:
Clinical Medicine
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542611/
https://ncbi.nlm.nih.gov/pubmed/30998508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127470
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